Elsyia

About

The new Elysia-Raytest relies on the long development and production experience from Raytest. The complete production and service team is based in Germany and guarantees the “Made in Germany” quality and experience in this scientific field.

Elysia-Raytest has identified the need to improve the user-friendliness and efficient workflow in Quality Control laboratories for Nuclear Medicine and radio-pharmaceutical producers, and meets these needs through the development of new detection technology and intuitively designed LIMS systems.

Country of Origin: Germany

Product:

Gaia

Gaia is a synthesis unit for the labeling of peptides such as DOTATOC or PSMA with radioactive metals (e.g. 68Ga). The software and operations were optimized with regards to a fast, simple and intuitive production of common radio tracers. A large list of specific methods ad synthesis kits is available and new methods can easily be adapted.

With its compact design, electrical connections reduced to a minimum and smooth surface, the device is easy to handle and to clean. All components in contact with reagents are part of single use kit to avoid cross or bacterial contaminations and to fulfill GMP demands. Thanks to the economized applications of single-use materials which are easily available, the running costs for the user are minimized.

 

Gaia V2


Gaia v2 is the second generation of our Gaia synthesis unit. Gaia v2 is a synthesis unit for the labelling of peptides such as DOTATOC or PSMA with radioactive metals (e.g. 68Ga). Software and operations are optimized to provide the fast, simple and intuitive production of common radio tracers.

Gaia v2 is compatible with the labelling kits and methods of the Gaia.

This enhancement has been designed to reduce the instruments size and so save and optimize hot cell space.

The door has been replaced by an easily removable splash plate for easy handling and cleaning. All components in contact with reagents are part of single use kit to avoid cross or bacterial contaminations and to fulfill GMP demands. Thanks to the economized applications of readily available single-use materials, the running costs are minimized.

– Radio HPLC

Radio-chromatography faces a range of challenges. Depending on the application, the isotope, the required sensitivity, dynamic range, resolution and radioprotection requirements may be very different.
Elysia-raytest provides different combinations of radio detectors for PET and SPECT with dedicated HPLC instruments.
We have developed special system combinations and modifications to deliver high performance solutions for dedicated applications. 
We provide ready-to-use solutions for the Quality control of different radio pharmaceutics such as 18F-FDG,
Each of these solutions can be delivered with 68Galium, 18F-choline, etc.
a optimised methodology, training, IQ/OQ and PQ.
Our solutions are mainly based on Shimadzu or Agilent HPLC systems and we can deliver a complete line of detectors including UV, Refractive Index Detector (RID), Pulse Amperometric Detector (PAD) and Diode Array Detector (DAD).
Elysia-Raytest devices can be connected to any existing HPLC system, either using digital data transfer or an analogue-to-digital converter. Nearly every complete radio-HPLC system can be controlled using one of our software platforms. 
In addition, we deliver a broad range of different HPLC pumps – from simple isocratic pumps up to quaternary µPLC pumps.

 

–  Mucha


Mucha is our multi-channel-analyser for ɣ-spectroscopy. The gamma radiation measuring system is designed for applications in nuclide laboratories for the determination of radio nuclide purity, for analysis of environmental samples or for determination of very low activities in food, water and waste samples.  Various scintillation probes of different sizes in suitable lead shielding are available for the Marinelli beaker covering the total crystal volume or for a sample vial installed in the central vial holder.  The operation of the multi-channel-analyser is simple and self-explanatory. The user is guided by dialog on the screen. The parameter selection and operation are performed by touching a soft key on the screen.  Every screen offers all operational functions as needed for the analysis to be performed.  Display of the measured spectrum is live.  Periodic automatic energy calibration is obtained by using a suitable Cs-137 calibration source. Extended calibration through a suitable multi-nuclides source is also possible. Selected energy regions are highlighted.  Selected nuclides are named with the activity unit. Background spectra can be accumulated and automatically subtracted for the selected measurement time at selected regions.  In order to offer a suitable spectrum display, a low, medium and high energy range can be selected.  At the end of any measurement the spectrum can be printed or transferred for further analysis or storage to a PC. Mucha is applied for radionuclide identification during radiopharmaceutical quality control (verification of radioisotope energy peak) and quantitative determination of radio-contaminants coming from cyclotron target or radioisotope generators.

– Gabi *


Gabi* is our radioactivity-HPLC-flow-monitor based on our well proven μ-processor controlled gamma spectrometer technology. GABI* is assembled in modules of 19” format, which make modification and service support very fast and easy. 
GABI* has a high voltage unit for manual or automatic selection of the required detector operation. Inserting a suitable calibration source and running the automatic calibration program, GABI* sets all parameters to a calibrated energy scale. Recalibration for compensation of any drift is easy, fast and fully automatic. GABI* has 2 simultaneous counting channels with 2 individually selectable energy thresholds each for setting an individual counting window for a particular nuclide. GABI* counts the radiation events in an energy channel per selected interval time. The information of counts per time is transferred to the GINA* program. The chromatogram is displayed live on screen. No overriding of ranges can happen. Peak integration, background subtraction, flow correction, absolute activity calculation etc. can be performed manually or automatically. 
Limit-of-detection is determined for every ROI, displayed and printed. GINA* and Clarity programs can control multiple modules of Agilent, Shimadzu or other HPLC providers. All data and parameters are stored under one identity code. GINA* can be installed in the background of the original HPLC-operation program and the user can use the operation program of the HPLC supplier as well as taking advantages of GINA*.

 

– PoMo


The PoMo is specially designed for radio flow monitoring or PET tracers. The detector represents the latest enhancements in flow detectors for radio HPLC.

Our High positron efficiency flow cells with low gamma response provide unique detection capabilities for PET isotope studies and ensure low background noise. The PoMo is perfectly suited for the quality control of PET tracers. 

QC-Cubicle


We  offer different extensions for the QC-cubicle. With the extension, the system is more flexible than the standard QC-Cubicle and allows the QC of different tracers and even R&D on new molecules.

It can easily be upgraded in the future and adapted to your personal needs. Just contact us and tell us a bit more about your plans and needs.

– QC-Cubicle Sample Preparation Module


The sample preparation module has been designed to optimize work flow whilst increasing radiation protection for the user. The integrated lead castle is designed to perform operations like thin-layer chromatography elution, sample preparation (dilution, vial filling, …,) and store contaminated tools (i.e HPLC syringe, vials).

It comes with built-in waste containers for daily production and decontamination and ease QC lab line clearance by allowing safe storage of still radioactive solutions or tools. The module is delivered with some special sample holders, small lead shielding for required vials, Eppendorf tubes and working tools to facilitate the work and to minimize the hands-on time. The automatic door opener for the waste makes the work smooth and easy.

MiniGita


MiniGITA* TLC is a scanning device, which moves a radioactivity detector along 1 trace from start to finish. The repeated, fast, continuous detection from start to finish and back compensates automatically for the radioactive decay of the compound over the scan length. 

We provide different detectors and collimators to achieve the best performance according to the customer needs and application. 

For ß-nuclides we use positron detector based on a small plastic scintillation probe. With this detector, the instrument can measure medium and high energy beta isotopes like 14[C], 90[Y], 18[F] 11[C] etc. The relative small size and fast respond time of the plastic scintillator allows to measure very high-count rates up to 500 000 cps and provides high sensitivity to positron emitters whilst significantly reducing background counts from non-positron emitting isotopes. 

For low energy y-nuclides like 99m[Tc] the positron detector can also be used to measure high activity samples starting from 20 KBq up to 20 MBq. 

 

 

– Raphaela ACG


The Elysia-raytest RAPHAELA ACG (previous name was BARES Batch recording & reporting system) is a data base LIMS system to acquire, record & report results from the individual instruments applied for radiopharmaceutical production and QC. It records automatically and digitally the QC information from the different measurement instruments required by law for the release of a radio-pharmaceutical tracer.

 

The software is preconfigured for 18F-FDG, but can also be easily used for other PET tracers like 18F-FEC, 18F-FET, etc. It can also collect data from the cyclotron, synthesis module, QC instruments & dispensing unit. It assembles automatically all information to one common analysis report. This contains the measured value and information regarding the level of acceptance. It also remarks if one value is out of the acceptance criteria or the required value is missing. The final report will be digitally signed when released by the responsible person.

– Safira Sterility Filter Test


SAFIRA is our automated sterile filter integrity test. The SAFIRA-System is used to verify the integrity of sterile filters. It provides a Hands-free inline sterile filter test in distribution lines. We have developed a method, which makes it possible to test the filter integrity immediately after a radiopharmaceutical synthesis without exposing the operator to radiation. SAFIRA can be implemented in existing radiopharmaceutical installations.

Up to 3 detection satellites can be controlled by one interface. The stand-alone version can be adapted to any PET synthesizer.